Blake Street was created during the city's railway boom in the 1870s. It was part of the surveys laid out by James McCullock (see McCullock Street). The street was named for Dominick Edward Blake, who went by Edward Blake (1833-1912). He was a lawyer and statesman.
Blake was recruited into politics by George Brown, and became leader of the Ontario Liberal Party in 1868. In 1871 he was elected the province's second premier. He left provincial politics to run in the 1872 federal election, in which he was re-elected. But the "dual mandate" rule that allowed a politician to sit simultaneously in a provincial and federal house had been abolished, so Blake chose to abandon his career in provincial politics.
He played a major role in exposing the government of Sir John A. Macdonald's complicity in the Pacific Scandal, which forced the prime minister to resign. Blake was the offered the prime ministership, but turned it down due to ill health.